Click to Return to Home Page
Log In | Register Now

       Help


















 


 


Easy Separation from Excipients
Clindamycin: Antibiotic

charts

PDF
Click here to view
printable Application Sheet

Note: Normally used to treat infections with anaerobic bacteria, this drug is indicated for use against protozoal diseases such as malaria. Also used for acne can be useful against some some MRSA infections. Clindamycin is marketed under various trade names including Dalacin, Cleocin, Evoclin and Duac as well in generic form.


Method Conditions


Column Cogent Bidentate C8™, 4µm, 100A
Catalog No. 40008-15P
Dimensions 4.6 x 150mm
Mobile Phase 40% Acetonitrile, 60% 10mM Phosphate Buffer, pH 7.5
Flow rate 1.0 mL/minute
Peaks Clindamycin
Injection Volume  20 µL
Detection UV 338 nm
Temperature 25°C


Discussion

This semi-synthetic antiobiotic is structurally related to lincomycin and the chromatogram shown of clindamycin is from a complex pharmaceutical formulation. Note the excellent peak shape and the selectivity from the excipients. The stability and robustness of the Cogent TYPE-C™ columns makes this an excellent choice for QC applications.

MW of the clindamcycin is 424.99 with a pKa of 7.6 and is soluble in water, pyridine, ethanol and DMF.






[TOP]

Privacy Statement             Copyright © 2005, MicroSolv Technology Corporation.             Site developed by Net Ink Designs.